Insulin Resistance Linked to Increased Risk of 26 Diseases and Early Death in Women

A groundbreaking study conducted by researchers at Shandong University in China has revealed a significant link between insulin resistance and an increased risk of 26 diseases, as well as a higher likelihood of early death in women. Insulin resistance, a condition where cells in the muscles, fat, and liver do not respond effectively to the hormone insulin, is widely recognized for its role in diabetes. However, this new research highlights its connection to a broader spectrum of health conditions, offering critical insights into disease prevention and early intervention.

Insulin resistance is linked to an increased risk of 26 diseases and early death in women, according to a new study from Shandong University. Photo: Unsplash

The Link Between Insulin Resistance and Multiple Diseases

The study, which analyzed data from nearly 430,000 participants in the UK Biobank project, found that higher levels of insulin resistance were associated with an elevated risk of various diseases, including obesity, hypertension, heart disease, gout, sciatica, and others. The findings, to be presented at the Annual Meeting of the European Association for the Study of Diabetes (EASD) in Spain, underscore the importance of early detection and management of insulin resistance to mitigate these risks.

Lead author Jing Wu from the department of endocrinology at Shandong Provincial Hospital explained, "We have shown that by assessing the degree of insulin resistance, it is possible to identify individuals who are at risk of developing multiple diseases. This provides a basis for early intervention measures to reduce the risk of disease and offers new ideas for prevention and treatment."

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Elevated Risk of Early Death in Women

One of the most alarming findings of the study was the link between insulin resistance and an increased risk of early death in women. The researchers discovered that for every one-unit increase in insulin resistance, women had an 11% higher risk of death. Interestingly, this association was not observed in men, indicating a gender-specific impact of insulin resistance on mortality.

Lower Risk of Certain Diseases

While insulin resistance was linked to an increased risk of 26 conditions, the study also found a decreased risk of five diseases, including Parkinson's disease and osteoporosis. For instance, a one-unit increase in insulin resistance was associated with a 16% lower risk of developing Parkinson's disease.

The Role of Lifestyle Factors

The causes of insulin resistance are not entirely understood, but factors such as excess weight, lack of physical activity, and poor diet are believed to play a significant role. Jing Wu emphasized the importance of public awareness, stating, "Raising public awareness of these modifiable factors is important, as it empowers individuals to take proactive steps towards better metabolic health."

Although the study did not focus on interventions, previous research suggests that lifestyle changes, including regular exercise and a balanced diet low in added sugars and refined carbohydrates, can help reduce insulin resistance and its associated health risks.

Source: Euronews