A new study finds regular aspirin use may reduce colorectal cancer risk, especially in those with unhealthy lifestyles. Consult with a doctor before starting aspirin.
In a recent study published in JAMA Oncology, researchers have found that regular aspirin use may reduce the risk of developing colorectal cancer, particularly among individuals with unhealthy lifestyles. The study suggests that even small doses of aspirin could have significant protective effects, potentially offering a preventive measure against one of the most common and deadly forms of cancer worldwide.
Study Highlights:
Scope and Participants: The study analyzed data from over 107,655 individuals participating in long-term health studies, such as the Nurses’ Health Study and the Health Professionals Follow-Up Study. Most participants were White, suggesting a need for more diverse research in future studies.
Lifestyle Factors: The study particularly noted the benefits of aspirin for participants with higher body mass indices (BMIs), smoking habits, and other risk factors associated with poor health. These participants saw an 18% reduction in colorectal cancer risk compared to non-users.
Dosage and Usage: The research defined regular aspirin use as consuming two or more regular-strength aspirin or six or more low-dose aspirin per week. This dosage was sufficient to demonstrate a protective effect, especially in those with less healthy lifestyles.
Potential Mechanisms: While the exact reasons for aspirin's protective effect are not fully understood, it is believed that aspirin may inhibit pro-inflammatory pathways that can lead to cancer development.
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Expert Opinions
Dr. Daniel Sikavi, the lead author of the study and a gastroenterologist at Mass General Brigham, emphasized that aspirin's benefits were more pronounced among those with multiple lifestyle risk factors. Dr. Christina Annunziata from the American Cancer Society noted the study's limitations, including its observational nature, but agreed that it highlights how modifiable lifestyle choices can impact cancer risk.
Dr. Raymond DuBois, a past president of the American Association for Cancer Research, and Dr. Jennifer Davids, chief of colon and rectal surgery at Boston Medical Center, both cautioned that while aspirin may offer benefits, it is not a substitute for maintaining a healthy lifestyle. They stressed the importance of consulting with healthcare providers before starting any regular aspirin regimen, due to potential risks such as gastrointestinal bleeding.
This study underscores the potential of regular aspirin use as a preventive measure against colorectal cancer, especially for those unable to make healthier lifestyle changes. However, it is crucial for individuals to consult with their doctors to weigh the benefits and risks of aspirin use. Maintaining a balanced diet, regular exercise, avoiding smoking, and limiting alcohol intake remain essential components of cancer prevention.
As research continues to evolve, understanding the role of aspirin in cancer prevention could provide a simple, yet effective, strategy for reducing the burden of colorectal cancer worldwide.
Source: CNN
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